Forlle’d scientists developed low molecules of Hyaluronic acid enabling them to cross the skin barrier deep into the dermal level and stabilize the extracellular environment by preventing dehydration, stimulating the synthesis of collagen and elastin, reducing external pressure and introducing anti oxidant activity.

Human body consists of cells that carry the physiological processes required for life and growth. These cells secrete to their extracellular environment substances that maintain the proper environment which is essential for their bioactivity, proliferation and movement (cytotaxis). With age the amount of these extracellular products declines which has a great influence on the ageing process.

Hyaluronic acid is one of the major components that surround the cells, it is a gelatinous substance (mucopolysaccharide) abandoned in skin, eyes, joints and brain. In the joints it has a lubrication function to make the slippage and movement of the bones better and in the skin it is located in the deep layers called the dermis, it absorbs a huge amount of moisture and together with collagen and elastin it gives skin elasticity, softness and volume.

The main reason why baby skin is full of moisture, elasticity and heals well is that it holds a lot of hyaluronic acid. As skin ages the amount of hyaluronic acid that maintains moisture dramatically decreases. In adult skin the amount of hyaluronic acid decreases up to 1/20 of baby’s which makes the skin lose volume, wrinkled and flabby.

Hyaluronic acid is the best moisturizing substance on earth since it holds 6000 g of water per gram and it is not affected by outside factors such as temperature or humidity. In order to maintain proper amount of these molecules in the skin and replenish those decomposed by enzymes such as hyaluronidases and metaloprotienases which are abandoned in the skin, these molecules have to be administered uniformly and on daily bases.

The best way to deliver this component without damaging the skin is with products that are applied topically, however this fact is not easy to accomplish and is a great challenge.

The regular hyaluronic acid molecular weight is about 1,200,000 which is 2.76 μ. Compared to the size of one cell which is 1 μ it is three times bigger and compared to the space between the horny layers of the epidermis which is 200-250 nanometers it is 13.8 times bigger, the reason If we apply hyauronic acid with high molecular mass to the skin, it can go as far as the surface and cannot be permeated into the deep skin.

Hyaluronic acid is distributed in mammalian eye’s vitreum, navel string, synovial fluid, skin, pericardial fluid, or serum. It also exists in cockscomb, sharkskin, shark’s cartilage and membrane covering streptococcus. Many methods has been developed that use hyalonidaze enzymes produced by bacterial propagation but this methods has microbial problem to make low molecular hyaluronic acid. In addition, it is difficult to be applied for the manufacturing industry because of the difficult control for the degree of decomposition of HA. Other method with alkali has many progresses compared to the former method. Nevertheless, the processing time is long, and hyaluronic acid’s molecular weight is about 50,000–100,000. Although it is effective for the water retention (moisture keeping) on the skin surface’s horny layer, it cannot meet the demands from cosmetic fields that need the care from the inside of the skin such as barrier zone or dermis.

Forlle’d scientists solved these problems by giving great attention to the traditional fermentation technology and produces low molecular hyaluronic acid by the malt or organic acid fermentation in the condition that hyaluronic acid contains minerals.

Know more:

Forlle’d method of Low molecular Hyaluronic acid production

Advantages of Low molecular Hyaluronic acid by Forlle’d